Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia.

Journal of abnormal psychology - 1 Nov 2008

Docherty Anna R, Sponheim Scott R

Abstract excerpt

The Val(158)Met polymorphism of the catechol-O-methyltransferase (COMT) gene has been associated with aspects of schizophrenia that are possibly related to the disorder's pathogenesis. The present study investigated the Val(158)Met polymorphism in relation to anhedonia--a construct central to negative schizotypy. Anhedonia and other schizotypal characteristics were assessed in relatives of patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Affective Symptoms
Share to Catechol O-Methyltransferase
Share to Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Psychiatric Status Rating Scales

Share to Psychotic Disorders

Share to Schizophrenic Psychology

Share to Schizotypal Personality Disorder

Share to Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 19025226
DOI: 10.1037/a0013745
PMCID: PMC2936689

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia.PMID 19025226Read ↗

Personality in relation to genetic liability for schizophrenia and bipolar disorder: differential associations with the COMT Val 108/158 Met polymorphism.Semantic proximity Read ↗

Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele.Semantic proximity Read ↗

COMT-by-sex interaction effect on psychosis proneness.Semantic proximity Read ↗

The COMT Met158 allele and violence in schizophrenia: a meta-analysis.Semantic proximity Read ↗

Interrogating the Relationship Between Schizotypy, the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism, and Neuronal Oscillatory Activity.Semantic proximity Read ↗

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior.Semantic proximity Read ↗

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia.Semantic proximity Read ↗

Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele.Semantic proximity Read ↗

Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder.Semantic proximity Read ↗

Anhedonia in schizophrenia: a distinct familial subtype?Semantic proximity Read ↗

Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.