Article
Direct evidence for the role of COOH terminus of mouse mammary tumor virus superantigen in determining T cell receptor V beta specificity.
The Journal of experimental medicine - 1 Aug 1993
Yazdanbakhsh K, Park C G, Winslow G M, Choi Y
Abstract excerpt
It has recently been shown that open reading frames in the 3' long terminal repeats of mouse mammary tumor viruses encode superantigens. These viral superantigens (vSAGs) stimulate most T cells expressing appropriate V beta s almost regardless of the rest of the variable components of the T cell receptors (TCR) expressed by those cells. vSAGs produce a type II integral membrane protein with a nonessential short...
Topics
- Amino Acid Sequence
- Antigens, Viral
- Base Sequence
- Carboxylic Acids
- Cell Membrane
- DNA, Single-Stranded
- Electrochemistry
- Epitopes
- Histocompatibility Antigens Class II
- Lysine
- Mammary Tumor Virus, Mouse