In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

doi:10.1084/jem.173.5.1165

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Article

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

The Journal of experimental medicine - 1 May 1991

Jacob J, Kassir R, Kelsoe G

Abstract excerpt

After primary immunization with an immunogenic conjugate of (4-hydroxy-3-nitrophenyl)acetyl, two anatomically and phenotypically distinct populations of antibody-forming cells arise in the spleen. As early as 2 d after immunization, foci of antigen-binding B cells are observed along the periphery of the periarteriolar lymphoid sheaths. These foci expand, occupying as much as 1% of the splenic volume by day 8 of...

Topics

Animals
Antibodies
Antibody Formation
Antigens
B-Lymphocytes
Base Sequence
Cell Division
DNA
Immunoglobulin Isotypes
Immunoglobulin Switch Region
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin lambda-Chains

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Molecular Sequence Data

Nitrophenols

Nucleic Acid Hybridization

Source

Open in PubMed Open full text

Identifiers

PMID: 1902502
DOI: 10.1084/jem.173.5.1165
PMCID: PMC2118845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1902502-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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