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Article

LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.

Neurogenetics - 1 Apr 2009

Gorostidi A, Ruiz-Martínez J, Lopez de Munain A, Alzualde A, Martí Massó J F

Abstract excerpt

Mutations in LRRK2 gene are the most frequent cause of Parkinson's disease (PD) described, but their prevalence varies between populations. Patients, 418, with PD and 138 unrelated controls from the Basque Country were screened for LRRK2 G2019S and R1441G mutations. Of the patients, 3.82% were heterozygous carriers of G2019S and 13.15% of R1441G. G2019S frequency was higher in non-Basque population (6.0%), while...

Topics

Adult
Aged
Aged, 80 and over
DNA Mutational Analysis
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Middle Aged
Mutation
Parkinson Disease
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spain

Source

Identifiers

PMID: 19020907
DOI: 10.1007/s10048-008-0162-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19020907-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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