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Article

Parkinson's disease due to the R1441G mutation in Dardarin: a founder effect in the Basques.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2006

Simón-Sánchez Javier, Martí-Massó José-Félix, Sánchez-Mut José Vicente, Paisán-Ruiz Coro, Martínez-Gil Angel, Ruiz-Martínez Javier, Sáenz Amets, Singleton Andrew B, López de Munain Adolfo, Pérez-Tur Jordi

Abstract excerpt

The recent discovery of mutations in Dardarin (LRRK2) have been related to the appearance of Parkinson's disease in several families. Notably, one single mutation in this gene (R1441G) not only appeared in familial, but also in apparently sporadic Parkinson disease (PD) patients of Basque descent. A clinical population was ascertained, and subjects were classified into Basque and non-Basque descent according to...

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PMID: 16991141
DOI: 10.1002/mds.21114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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