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Article

Association between reduced folate carrier G80A polymorphism and methotrexate toxicity in childhood acute lymphoblastic leukemia: a meta-analysis.

Leukemia & lymphoma - 1 Dec 2014

He Hai-Rong, Liu Ping, He Gong-Hao, Dong Wei-Hua, Wang Mao-Yi, Dong Ya-Lin, Lu Jun

Abstract excerpt

Abstract Methotrexate (MTX) is a key component of chemotherapeutic regimens for childhood acute lymphoblastic leukemia (ALL), and enters the cell via active transport mediated by the reduced folate carrier (RFC1). A major single-nucleotide polymorphism of the RFC1 gene, G80A, which affects the activity of RFC1, may influence MTX toxicity in pediatric ALL. We collected all studies that investigated the association...

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Source

Identifiers

PMID: 24597986
DOI: 10.3109/10428194.2014.898761

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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