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Article

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.

Annals of the rheumatic diseases - 1 Nov 2009

Abelson A-K, Delgado-Vega A M, Kozyrev S V, Sánchez E, Velázquez-Cruz R, Eriksson N, Wojcik J, Linga Reddy M V P, Lima G, D'Alfonso S, Migliaresi S, Baca V, Orozco L, Witte T, Ortego-Centeno N, Abderrahim H, Pons-Estel B A, Gutiérrez C, Suárez A, González-Escribano M F, Martin J, Alarcón-Riquelme M E

Abstract excerpt

OBJECTIVES: To confirm and define the genetic association of STAT4 and systemic lupus erythematosus (SLE), investigate the possibility of correlations with differential splicing and/or expression levels, and genetic interaction with IRF5. METHODS: 30 tag SNPs were genotyped in an independent set...

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Source

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Identifiers

PMID: 19019891
DOI: 10.1136/ard.2008.097642
PMCID: PMC3878433

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19019891-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.PMID 19019891Read ↗

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.Semantic proximity Read ↗

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.Semantic proximity Read ↗

STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis.Semantic proximity Read ↗

Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort.Semantic proximity Read ↗

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4.Semantic proximity Read ↗

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.Semantic proximity Read ↗

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.Semantic proximity Read ↗

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.Semantic proximity Read ↗

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.Semantic proximity Read ↗

Genetic polymorphisms in genes involved in the type I interferon system (STAT4 and IRF5): association with Asian SLE patients.Semantic proximity Read ↗

Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population.Semantic proximity Read ↗

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

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