Article
STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.
Annals of the rheumatic diseases - 1 Nov 2009
Abelson A-K, Delgado-Vega A M, Kozyrev S V, Sánchez E, Velázquez-Cruz R, Eriksson N, Wojcik J, Linga Reddy M V P, Lima G, D'Alfonso S, Migliaresi S, Baca V, Orozco L, Witte T, Ortego-Centeno N, Abderrahim H, Pons-Estel B A, Gutiérrez C, Suárez A, González-Escribano M F, Martin J, Alarcón-Riquelme M E
Abstract excerpt
OBJECTIVES: To confirm and define the genetic association of STAT4 and systemic lupus erythematosus (SLE), investigate the possibility of correlations with differential splicing and/or expression levels, and genetic interaction with IRF5. METHODS: 30 tag SNPs were genotyped in an independent set of Spanish cases and controls. SNPs surviving correction for multiple tests were genotyped in five new sets of cases...
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