STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

doi:10.1056/NEJMoa073003

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Article

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

The New England journal of medicine - 6 Sept 2007

Remmers Elaine F, Plenge Robert M, Lee Annette T, Graham Robert R, Hom Geoffrey, Behrens Timothy W, de Bakker Paul I W, Le Julie M, Lee Hye-Soon, Batliwalla Franak, Li Wentian, Masters Seth L, Booty Matthew G, Carulli John P, Padyukov Leonid, Alfredsson Lars, Klareskog Lars, Chen Wei V, Amos Christopher I, Criswell Lindsey A, Seldin Michael F, Kastner Daniel L, Gregersen Peter K

Abstract excerpt

BACKGROUND: Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q. METHODS: We tested single-nucleotide polymorphisms (SNPs) in and around 13 candidate genes within the previously linked chromosome 2q region for association with rheumatoid arthritis. We then performed fine mapping of the STAT1-STAT4...

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Identifiers

PMID: 17804842
DOI: 10.1056/NEJMoa073003
PMCID: PMC2630215

Genes

STAT4
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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