A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

doi:10.1093/hmg/ddn184

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Article

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

Human molecular genetics - 15 Sept 2008

Sigurdsson Snaevar, Nordmark Gunnel, Garnier Sophie, Grundberg Elin, Kwan Tony, Nilsson Olof, Eloranta Maija-Leena, Gunnarsson Iva, Svenungsson Elisabet, Sturfelt Gunnar, Bengtsson Anders A, Jönsen Andreas, Truedsson Lennart, Rantapää-Dahlqvist Solbritt, Eriksson Catharina, Alm Gunnar, Göring Harald H H, Pastinen Tomi, Syvänen Ann-Christine, Rönnblom Lars

Abstract excerpt

Systemic lupus erythematosus (SLE) is the prototype autoimmune disease where genes regulated by type I interferon (IFN) are over-expressed and contribute to the disease pathogenesis. Because signal transducer and activator of transcription 4 (STAT4) plays a key role in the type I IFN receptor signaling, we performed a candidate gene study of a comprehensive set of single nucleotide polymorphism (SNPs) in STAT4 in...

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PMID: 18579578
DOI: 10.1093/hmg/ddn184
PMCID: PMC2525501

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STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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