Article
Design of a bZip transcription factor with homo/heterodimer-induced DNA-binding preference.
Structure (London, England : 1993) - 4 Mar 2014
Pogenberg Vivian, Consani Textor Larissa, Vanhille Laurent, Holton Simon J, Sieweke Michael H, Wilmanns Matthias
Abstract excerpt
The ability of basic leucine zipper transcription factors for homo- or heterodimerization provides a paradigm for combinatorial control of eukaryotic gene expression. It has been unclear, however, how facultative dimerization results in alternative DNA-binding repertoires on distinct regulatory elements. To unravel the molecular basis of such coupled preferences, we determined two high-resolution structures of...
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