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Article

Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.

Antimicrobial agents and chemotherapy - 1 Feb 2009

Fortwendel Jarrod R, Juvvadi Praveen Rao, Pinchai Nadthanan, Perfect B Zachary, Alspaugh J Andrew, Perfect John R, Steinbach William J

Abstract excerpt

Aspergillus fumigatus must be able to properly form hyphae and maintain cell wall integrity in order to establish invasive disease. Ras proteins and calcineurin each have been implicated as having roles in these processes. Here, we further delineate the roles of calcineurin and Ras activity in cell wall biosynthesis and hyphal morphology using genetic and pharmacologic tools. Strains deleted for three genes...

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Identifiers

PMID: 19015336
DOI: 10.1128/AAC.01154-08
PMCID: PMC2630655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.PMID 19015336Read ↗

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