Article
Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.
Eukaryotic cell - 1 Jul 2006
Steinbach William J, Cramer Robert A, Perfect B Zachary, Asfaw Yohannes G, Sauer Theodor C, Najvar Laura K, Kirkpatrick William R, Patterson Thomas F, Benjamin Daniel K, Heitman Joseph, Perfect John R
Abstract excerpt
Calcineurin is implicated in a myriad of human diseases as well as homeostasis and virulence in several major human pathogenic microorganisms. The fungus Aspergillus fumigatus is a leading cause of infectious death in the rapidly expanding immunocompromised patient population. Current antifungal treatments for invasive aspergillosis are often ineffective, and novel therapeutic approaches are urgently needed. We...
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