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Article

Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.

Antimicrobial agents and chemotherapy - 1 Aug 2007

Steinbach William J, Cramer Robert A, Perfect B Zachary, Henn Christina, Nielsen Kirsten, Heitman Joseph, Perfect John R

Abstract excerpt

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

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Identifiers

PMID: 17502415
DOI: 10.1128/AAC.01394-06
PMCID: PMC1932494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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