Article
Calcineurin is essential for Candida albicans survival in serum and virulence.
Eukaryotic cell - 1 Jun 2003
Blankenship Jill R, Wormley Floyd L, Boyce Molly K, Schell Wiley A, Filler Scott G, Perfect John R, Heitman Joseph
Abstract excerpt
Calcineurin is a calcium-activated protein phosphatase that is the target of the immunosuppressants cyclosporin A and FK506. In T cells, calcineurin controls nuclear import of the NF-AT transcription factor and gene activation. In plants and fungi, calcineurin functions in stress responses (e.g., temperature, cations, and pH) and is necessary for the virulence of the fungal pathogen Cryptococcus neoformans. Here...
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