Article
Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.
Antimicrobial agents and chemotherapy - 1 Apr 2010
Miyazaki Taiga, Yamauchi Shunsuke, Inamine Tatsuo, Nagayoshi Yosuke, Saijo Tomomi, Izumikawa Koichi, Seki Masafumi, Kakeya Hiroshi, Yamamoto Yoshihiro, Yanagihara Katsunori, Miyazaki Yoshitsugu, Kohno Shigeru
Abstract excerpt
A Candida glabrata calcineurin mutant exhibited increased susceptibility to both azole antifungal and cell wall-damaging agents and was also attenuated in virulence. Although a mutant lacking the downstream transcription factor Crz1 displayed a cell wall-associated phenotype intermediate to that of the calcineurin mutant and was modestly attenuated in virulence, it did not show increased azole susceptibility....
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