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Article

The xylosyltransferase Iota gene polymorphism c.343G>T (p.A115S) is associated with decreased serum glycosaminoglycan levels.

Clinical biochemistry - 1 Jan 2009

Ambrosius Michael, Kleesiek Knut, Götting Christian

Abstract excerpt

OBJECTIVES: The xylosyltransferases I and II (XT-I, XT-II, EC 2.4.2.26) are the chain-initiating enzymes in the biosynthesis of glycosaminoglycans (GAGs). This is the first investigation of changes in the serum GAG amount and composition in association with polymorphisms in XYLT1 and XYLT2. DESIGN AND METHODS: Genotyping of three genetic variations in the genes XYLT1 and XYLT2 was performed in 223 healthy blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19014925
DOI: 10.1016/j.clinbiochem.2008.10.013

Genes

XYLT1
XYLT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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