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Mutational and functional analyses of xylosyltransferases and their implication in osteoarthritis.

Osteoarthritis and cartilage - 1 May 2006

Schön S, Huep G, Prante C, Müller S, Christ R, Hagena F-W, Kuhn J, Kleesiek K, Götting C

Abstract excerpt

OBJECTIVE: The hallmark in osteoarthritis (OA) is the loss of proteoglycans (PGs) in articular cartilage (AC). Xylosyltransferase I (XT-I) catalyzes the transfer of xylose to serine residues in the core protein and initiates the biosynthesis of PGs in AC. The XYLT-II gene encodes a highly homologous protein but its biological function is not yet known. Here we investigate for the first time genetic variations in...

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PMID: 16376579
DOI: 10.1016/j.joca.2005.11.004

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Source receipt: pubmed, retrieved 7 Sept 2026.

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