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Mutational and functional analyses of xylosyltransferases and their implication in osteoarthritis.

Osteoarthritis and cartilage - 1 May 2006

Schön S, Huep G, Prante C, Müller S, Christ R, Hagena F-W, Kuhn J, Kleesiek K, Götting C

Abstract excerpt

OBJECTIVE: The hallmark in osteoarthritis (OA) is the loss of proteoglycans (PGs) in articular cartilage (AC). Xylosyltransferase I (XT-I) catalyzes the transfer of xylose to serine residues in the core protein and initiates the biosynthesis of PGs in AC. The XYLT-II gene encodes a highly homolog...

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PMID: 16376579
DOI: 10.1016/j.joca.2005.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16376579-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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