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Article

Identification and characterization of human xylosyltransferase II promoter single nucleotide variants.

Biochemical and biophysical research communications - 20 Mar 2015

Faust Isabel, Böker Kai Oliver, Eirich Christina, Akkermann Dagmar, Kuhn Joachim, Knabbe Cornelius, Hendig Doris

Abstract excerpt

The human isoenzymes xylosyltransferase-I and -II (XT-I, XT-II) catalyze the rate-limiting step in proteoglycan biosynthesis. Therefore, serum XT activity, mainly representing XT-II activity, displays a powerful biomarker to quantify the actual proteoglycan synthesis rate. Serum XT activity is increased up to 44% in disorders which are characterized by an altered proteoglycan metabolism, whereby underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25704086
DOI: 10.1016/j.bbrc.2015.02.056

Genes

XYLT2

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