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Article

Human xylosyltransferase I and N-terminal truncated forms: functional characterization of the core enzyme.

The Biochemical journal - 15 Feb 2006

Müller Sandra, Disse Jennifer, Schöttler Manuela, Schön Sylvia, Prante Christian, Brinkmann Thomas, Kuhn Joachim, Kleesiek Knut, Götting Christian

Abstract excerpt

Human XT-I (xylosyltransferase I; EC 2.4.2.26) initiates the biosynthesis of the glycosaminoglycan linkage region and is a diagnostic marker of an enhanced proteoglycan biosynthesis. In the present study, we have investigated mutant enzymes of human XT-I and assessed the impact of the N-terminal region on the enzymatic activity. Soluble mutant enzymes of human XT-I with deletions at the N-terminal domain were...

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Identifiers

PMID: 16225459
DOI: 10.1042/BJ20051606
PMCID: PMC1386014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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