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Article

Identification of a xylosyltransferase II gene haplotype marker for diabetic nephropathy in type 1 diabetes.

Clinica chimica acta; international journal of clinical chemistry - 1 Dec 2008

Hendig Doris, Tarnow Lise, Kuhn Joachim, Kleesiek Knut, Götting Christian

Abstract excerpt

BACKGROUND: Proteoglycans are major components of the glomerular basement membrane, being responsible for their permeability properties. Type 1 diabetic patients have an altered proteoglycan metabolism, which contributes to microvascular complications like diabetic nephropathy. Xylosyltransferase II (XT-II) is a chain-initiating enzyme in the biosynthesis of basement membrane proteoglycans and catalyzes the...

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Source

Identifiers

PMID: 18789912
DOI: 10.1016/j.cca.2008.08.019

Genes

XYLT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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