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Article

Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2005

Götting Christian, Hendig Doris, Adam Alexandra, Schön Sylvia, Schulz Veronika, Szliska Christiane, Kuhn Joachim, Kleesiek Knut

Abstract excerpt

Pseudoxanthoma elasticum (PXE) is a hereditary disorder of the connective tissue characterized by extracellular matrix alterations with elastin fragmentation and excessive proteoglycan deposition. Xylosyltransferase I (XT-I, E.C. 2.4.2.26) is the initial enzyme in the biosynthesis of the glycosaminoglycan chains in proteoglycans and has been shown to be a marker of tissue remodeling processes. Here, we...

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Source

Identifiers

PMID: 16133423
DOI: 10.1007/s00109-005-0693-x

Genes

AGT
ABCC6

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis.PMID 16133423Read ↗

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