Article
Xylosyltransferase I variants and their impact on abdominal aortic aneurysms.
Clinica chimica acta; international journal of clinical chemistry - 1 May 2008
Götting Christian, Prante Christian, Schillinger Martin, Exner Markus, Domanovits Hans, Raith Marianne, Kuhn Joachim, Kleesiek Knut
Abstract excerpt
BACKGROUND: The formation of abdominal aortic aneurysm (AAA) is caused by a destructive remodeling of the extracellular matrix in the vascular wall. Proteoglycan content and biosynthesis have been shown to be altered in AAA. Xylosyltransferase I (XT-I) is the initial and rate-limiting enzyme in the biosynthesis of the proteoglycan-linked glycosaminoglycan chains. A familial predisposition to AAA is well...
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