Article
Expression of the reverse tetracycline-transactivator gene causes emphysema-like changes in mice.
American journal of respiratory cell and molecular biology - 1 May 2006
Sisson Thomas H, Hansen Jean M, Shah Mitali, Hanson Kerstin E, Du Ming, Ling Tony, Simon Richard H, Christensen Paul J
Abstract excerpt
The doxycycline-inducible, gene regulatory system allows tight control of transgene expression for the study of organ development and disease pathogenesis. Multiple recent reports have employed this model to investigate various lung diseases including emphysema. For our study, we used this transgenic system to test whether prolonged, lung-specific, overexpression of the serine protease urokinase plasminogen...
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