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Article

Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice.

The Journal of biological chemistry - 26 Dec 2003

Bridges James P, Wert Susan E, Nogee Lawrence M, Weaver Timothy E

Abstract excerpt

Surfactant Protein C (SP-C) is a secreted transmembrane protein that is exclusively expressed by alveolar type II epithelial cells of the lung. SP-C associates with surfactant lipids to reduce surface tension within the alveolus, maintaining lung volume at end expiration. Mutations in the gene encoding SP-C (SFTPC) have recently been linked to chronic lung disease in children and adults. The goal of this study...

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Source

Identifiers

PMID: 14525980
DOI: 10.1074/jbc.M309599200

Genes

SFTPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice.PMID 14525980Read ↗

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