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Article

Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice.

American journal of respiratory cell and molecular biology - 1 Jan 2002

Conkright Juliana Johnson, Na Cheng-Lun, Weaver Timothy E

Abstract excerpt

Surfactant replacement preparations containing either surfactant protein (SP)-B or SP-C significantly improve lung function in surfactant-deficient infants, suggesting that these peptides may be functionally redundant. SP-B is absent and SP-C is greatly diminished in the airspaces of SP-B (-/-) mice, which die of respiratory distress syndrome (RDS) shortly after birth. The goal of this study was to determine if...

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Identifiers

PMID: 11751207
DOI: 10.1165/ajrcmb.26.1.4686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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