Conditional Expression of Genes in the Respiratory Epithelium in Transgenic Mice

Abstract excerpt

Cautionary Notes and Toward Building a Better Mouse TrapIn vitro and in vivo studies have repeatedly demonstrated the limitations and potential toxicity of various genes (proteins) used for both labeling cells (e.g., with green fluorescent protein [GFP], b-galactosidase, and luciferase) or for the deletion/addition of mutation of genes (e.g., reverse tetracycline transactivator protein [rtTA], tetracycline...

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