A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.

doi:10.1093/emboj/21.7.1565

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A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.

The EMBO journal - 2 Apr 2002

Butty Anne-Christine, Perrinjaquet Nathalie, Petit Audrey, Jaquenoud Malika, Segall Jeffrey E, Hofmann Kay, Zwahlen Catherine, Peter Matthias

Abstract excerpt

In Saccharomyces cerevisiae, activation of Cdc42 by its guanine-nucleotide exchange factor Cdc24 triggers polarization of the actin cytoskeleton at bud emergence and in response to mating pheromones. The adaptor protein Bem1 localizes to sites of polarized growth where it interacts with Cdc42, Cdc24 and the PAK-like kinase Cla4. We have isolated Bem1 mutants (Bem1-m), which are specifically defective for binding...

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A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.

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A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.

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