Article
APC activation restores functional CD4(+)CD25(+) regulatory T cells in NOD mice that can prevent diabetes development.
PloS one - 1 Jan 2008
Manirarora Jean N, Kosiewicz Michele M, Parnell Sarah A, Alard Pascale
Abstract excerpt
BACKGROUND: Defects in APC and regulatory cells are associated with diabetes development in NOD mice. We have shown previously that NOD APC are not effective at stimulating CD4(+)CD25(+) regulatory cell function in vitro. We hypothesize that failure of NOD APC to properly activate CD4(+)CD25(+) regulatory cells in vivo could compromise their ability to control pathogenic cells, and activation of NOD APC could...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.