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Transforming Growth Factor β: Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?

14 Nov 2008

Abstract excerpt

Therapies targeting transforming growth factor beta (TGFbeta) signaling using neutralizing antibodies and small molecular inhibitors are in multiple clinical trails. However, TGFbeta is known to work as both a tumor suppressor and a tumor promoter, and current knowledge does not provide sufficient information on what factors mediate this switch in function and when this switch occurs. Recent advances in multiple...

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PMID: 19010878
DOI: 10.1158/0008-5472.can-08-2556

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