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Article

TGF-beta: a master immune regulator

31 Mar 2020

Abstract excerpt

Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression. Since the immune checkpoint pathways are co-opted in cancer to induce T cell tolerance, this review posits that TGF-β is a master checkpoint in cancer, whose negative regulatory...

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PMID: 32228232
DOI: 10.1080/14728222.2020.1744568

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