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Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

23 Oct 2020

Abstract excerpt

Transforming growth factor-β (TGF-β) was originally identified as an anti-tumour cytokine. However, there is increasing evidence that it has important roles in the tumour microenvironment (TME) in facilitating cancer progression. TGF-β actively shapes the TME via modulating the host immunity. These actions are highly cell-type specific and complicated, involving both canonical and non-canonical pathways. In this...

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PMID: 33114183
DOI: 10.3390/cancers12113099

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