Article
The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Stokes Kyle, Nunes Malika, Trombley Chantelle, Flôres Danilo E F L, Wu Gang, Taleb Zainab, Alkhateeb Abedalrhman, Banskota Suhrid, Harris Chris, Love Oliver P, Khan Waliul I, Rueda Luis, Hogenesch John B, Karpowicz Phillip
Abstract excerpt
BACKGROUND & AIMS: Circadian rhythms are daily physiological oscillations driven by the circadian clock: a 24-hour transcriptional timekeeper that regulates hormones, inflammation, and metabolism. Circadian rhythms are known to be important for health, but whether their loss contributes to colorectal cancer is not known. We tested the nonredundant clock gene Bmal1 in intestinal homeostasis and tumorigenesis,...
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