Article
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997
Holgado-Madruga M, Moscatello D K, Emlet D R, Dieterich R, Wong A J
Abstract excerpt
Nerve growth factor (NGF) prevents apoptosis through stimulation of the TrkA receptor protein tyrosine kinase. The downstream activation of phosphatidylinositol 3-kinase (PI 3-kinase) is essential for the inhibition of apoptosis, although this enzyme does not bind to and is not directly activated...
Topics
- Animals
- Apoptosis
- Cell Survival
- Mutation
- Nerve Growth Factors
- PC12 Cells
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Rats
- Signal Transduction