Article
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997
Holgado-Madruga M, Moscatello D K, Emlet D R, Dieterich R, Wong A J
Abstract excerpt
Nerve growth factor (NGF) prevents apoptosis through stimulation of the TrkA receptor protein tyrosine kinase. The downstream activation of phosphatidylinositol 3-kinase (PI 3-kinase) is essential for the inhibition of apoptosis, although this enzyme does not bind to and is not directly activated by TrkA. We have found that the addition of NGF to PC-12 cells resulted in the phosphorylation of the Grb2-associated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.