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Article

Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells.

Cellular signalling - 1 Jul 2005

Wu Eddy H T, Wong Yung H

Abstract excerpt

In Galpha(z)-deficient mice, survival of sympathetic neurons is significantly attenuated in the presence of pertussis toxin (PTX). This suggests that G(i/o) proteins may have distinct roles in neuronal survival. Here, we investigated the possible involvement of G(i/o) proteins in nerve growth factor (NGF)-induced pro-survival phosphatidylinositol-3-kinase (PI3K)/Akt signaling in rat pheochromocytoma PC12 cells....

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Share to bcl-Associated Death Protein
Share to GTP-Binding Protein alpha Subunits, Gi-Go

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Source

Identifiers

PMID: 15763430
DOI: 10.1016/j.cellsig.2004.11.008

Genes

NGF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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