Article
Cyclic AMP-induced neuronal differentiation via activation of p38 mitogen-activated protein kinase.
Journal of neurochemistry - 1 Nov 2000
Hansen T O, Rehfeld J F, Nielsen F C
Abstract excerpt
The p38 mitogen-activated protein kinase (MAPK) pathway mediates cellular responses to inflammatory cytokines and environmental stress, but recent studies have indicated that p38 MAPK may be involved in a more widespread set of cellular functions. Here we show that activation of the cyclic AMP (cAMP) pathway induces a rapid, dose-dependent phosphorylation and activation of p38 MAPK and that combined stimulation...
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