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Article

Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly.

Molecular biology of the cell - 1 Jan 2009

Schaeffer Céline, Santambrogio Sara, Perucca Simone, Casari Giorgio, Rampoldi Luca

Abstract excerpt

Uromodulin is the most abundant protein secreted in urine, in which it is found as a high-molecular-weight polymer. Polymerization occurs via its zona pellucida (ZP) domain, a conserved module shared by many extracellular eukaryotic proteins that are able to assemble into matrices. In this work, we identified two motifs in uromodulin, mapping in the linker region of the ZP domain and in between protein cleavage...

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Identifiers

PMID: 19005207
DOI: 10.1091/mbc.e08-08-0876
PMCID: PMC2626557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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