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Article

Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly.

Molecular biology of the cell - 1 Jan 2009

Schaeffer Céline, Santambrogio Sara, Perucca Simone, Casari Giorgio, Rampoldi Luca

Abstract excerpt

Uromodulin is the most abundant protein secreted in urine, in which it is found as a high-molecular-weight polymer. Polymerization occurs via its zona pellucida (ZP) domain, a conserved module shared by many extracellular eukaryotic proteins that are able to assemble into matrices. In this work,...

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Identifiers

PMID: 19005207
DOI: 10.1091/mbc.e08-08-0876
PMCID: PMC2626557

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19005207-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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