Article

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

2019-03-28

Abstract excerpt

Interaction between sperm and the egg zona pellucida (ZP) is the first step of mammalian fertilization, and ZP component ZP1 is important for fertility by covalently cross-linking ZP filaments into a matrix. Like ZP4, a structurally-related subunit absent in the mouse, ZP1 is predicted to contain an N-terminal ZP-N domain of unknown function. Characterization of ZP1 proteins carrying mutations from infertile patie...

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Literature Corpus work: 653b4d49-eabc-5fea-96e5-10dc20e55252
DOI: 10.1101/591966

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