Article

Uromodulin velcro sheets and their interaction with uropathogenic <i>E. coli</i>

2025-05-11

Abstract excerpt

<h4>SUMMARY</h4> Homopolymeric uromodulin (UMOD), the most abundant protein in human urine, protects against urinary tract infections (UTI) by acting as a decoy for uropathogenic E. coli (UPEC). Using cryo-electron tomography (ET), we show that urinary UMOD filaments naturally form sheets that interact with UPEC type I pili. Sheet formation is salt-dependent, and we resolve their high-resolution structure using...

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Literature Corpus work: c9952148-d5d0-5fb0-9b2b-025b8d607a5d
DOI: 10.1101/2025.05.09.653020

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