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Article

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

12 Jul 2019

Abstract excerpt

Mammalian fertilisation begins when sperm interacts with the egg zona pellucida (ZP), whose ZP1 subunit is important for fertility by covalently cross-linking ZP filaments into a three-dimensional matrix. Like ZP4, a structurally-related component absent in the mouse, ZP1 is predicted to contain an N-terminal ZP-N domain of unknown function. Here we report a characterisation of ZP1 proteins carrying mutations...

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PMID: 31300655
DOI: 10.1038/s41467-019-10931-5

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