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Article

A C. elegans Zona Pellucida domain protein functions via its ZPc domain.

PLoS genetics - 1 Nov 2020

Cohen Jennifer D, Bermudez Jessica G, Good Matthew C, Sundaram Meera V

Abstract excerpt

Zona Pellucida domain (ZP) proteins are critical components of the body's external-most protective layers, apical extracellular matrices (aECMs). Although their loss or dysfunction is associated with many diseases, it remains unclear how ZP proteins assemble in aECMs. Current models suggest that ZP proteins polymerize via their ZPn subdomains, while ZPc subdomains modulate ZPn behavior. Using the model organism...

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Identifiers

PMID: 33141826
DOI: 10.1371/journal.pgen.1009188
PMCID: PMC7665627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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