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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

1 Mar 2024

Abstract excerpt

Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP) hardens and polyspermy is irreversibly blocked. These events are associated with the cleavage of the N-terminal region (NTR) of glycoprotein ZP2, a major subunit of ZP filaments. ZP2 processing is thought to inactivate sperm binding to the ZP, but its molecular consequences and connection with ZP hardening are unknown....

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PMID: 38490181
DOI: 10.1016/j.cell.2024.02.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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