Article
Polymorphism in the microglial cell-mobilizing CX3CR1 gene is associated with survival in patients with glioblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Dec 2008
Rodero Mathieu, Marie Yannick, Coudert Mathieu, Blondet Emmeline, Mokhtari Karima, Rousseau Audrey, Raoul William, Carpentier Catherine, Sennlaub Florian, Deterre Philippe, Delattre Jean-Yves, Debré Patrice, Sanson Marc, Combadière Christophe
Abstract excerpt
PURPOSE: Few reliable prognostic molecular markers have been characterized for glioblastoma multiforme (GBM), considered the deadliest of human cancers. We hypothesized that genetic polymorphisms in chemokines and their receptors, which together control microglial cell mobilization, may influence...
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