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Article

Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain.

Psychiatry and clinical neurosciences - 1 Jun 2018

Sakai Mai, Takeuchi Hikaru, Yu Zhiqian, Kikuchi Yoshie, Ono Chiaki, Takahashi Yuta, Ito Fumiaki, Matsuoka Hiroo, Tanabe Osamu, Yasuda Jun, Taki Yasuyuki, Kawashima Ryuta, Tomita Hiroaki

Abstract excerpt

AIM: CX3CR1, a G-protein-coupled receptor, is involved in various inflammatory processes. Two non-synonymous single nucleotide polymorphisms, V249I (rs3732379) and T280M (rs3732378), are located in the sixth and seventh transmembrane domains of the CX3CR1 protein, respectively. Previous studies have indicated significant associations between T280M and leukocyte functional characteristics, including adhesion,...

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PMID: 29485193
DOI: 10.1111/pcn.12649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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