Article
Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients.
Journal of neuro-oncology - 1 Jan 2018
Jacobs Daniel I, Liu Yanhong, Gabrusiewicz Konrad, Tsavachidis Spiridon, Armstrong Georgina N, Zhou Renke, Wei Jun, Ivan Cristina, Calin George, Molinaro Annette M, Rice Terri, Bracci Paige M, Hansen Helen M, Wiencke John K, Wrensch Margaret R, Heimberger Amy B, Bondy Melissa L
Abstract excerpt
Immune cells of myeloid origin, including microglia, macrophages, and myeloid-derived suppressor cells adopt immunosuppressive phenotypes that support gliomagenesis. Here, we tested an a priori hypothesis that single nucleotide polymorphisms (SNPs) in genes related to glioma-associated myeloid cell regulation and function are also associated with patient survival after glioma diagnosis. Subjects for this study...
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