Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common polymorphisms of chemokine (C-X3-C motif) receptor 1 gene modify amyotrophic lateral sclerosis outcome: A population-based study.

Muscle & nerve - 1 Feb 2018

Calvo Andrea, Moglia Cristina, Canosa Antonio, Cammarosano Stefania, Ilardi Antonio, Bertuzzo Davide, Traynor Bryan J, Brunetti Maura, Barberis Marco, Mora Gabriele, Casale Federico, Chiò Adriano

Abstract excerpt

INTRODUCTION: In the brain, the chemokine (C-X3-C motif) receptor 1 (1CX3CR1) gene is expressed only by microglia, where it acts as a key mediator of the neuron-microglia interactions. We assessed whether the 2 common polymorphisms of the CX3CR1 gene (V249I and T280M) modify amyotrophic lateral sclerosis (ALS) phenotype. METHODS: The study included 755 ALS patients diagnosed in Piemonte between 2007 and 2012 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CX3C Chemokine Receptor 1

Share to Inflammation

Share to Kaplan-Meier Estimate

Share to Population

Share to Protein Array Analysis

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 28342179
DOI: 10.1002/mus.25653
PMCID: PMC5912184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common polymorphisms of chemokine (C-X3-C motif) receptor 1 gene modify amyotrophic lateral sclerosis outcome: A population-based study.PMID 28342179Read ↗

CX3CR1 is a modifying gene of survival and progression in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Association of the CX3CR1-V249I Variant with Neurofibrillary Pathology Progression in Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

Polymorphism in the microglial cell-mobilizing CX3CR1 gene is associated with survival in patients with glioblastoma.Semantic proximity Read ↗

Prospective study of common variants in CX3CR1 and risk of macular degeneration: pooled analysis from 5 long-term studies.Semantic proximity Read ↗

Lack of association between CX3CR1 V249I and T280M polymorphisms and risk of Parkinson's disease in a Greek population.Semantic proximity Read ↗

A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis.Semantic proximity Read ↗

An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians.Semantic proximity Read ↗

The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis.Semantic proximity Read ↗

An association study between polymorphisms of the fractalkine receptor gene, CX3CR1, and cerebral infarction in the Han Chinese population.Semantic proximity Read ↗

Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain.Semantic proximity Read ↗

Associations Between the T280M and V249I SNPs in CX3CR1 and the Risk of Age-Related Macular Degeneration.Semantic proximity Read ↗

Common CX3CR1 alleles are associated with a reduced risk of headaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.