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Article

Role of CX3CR1 signaling in malignant transformation of gliomas

31 Mar 2020

Abstract excerpt

BACKGROUND: Chemokine signaling may contribute to progression of low-grade gliomas (LGGs) by altering tumor behavior or impacting the tumor microenvironment. In this study, we investigated the role of CX3C chemokine receptor 1 (CX3CR1) signaling in malignant transformation of LGGs. METHODS: Ninety patients with LGGs were genotyped for the presence of common CX3CR1 V249I polymorphism and examined for...

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PMID: 32236410
DOI: 10.1093/neuonc/noaa075

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