Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression.

Abstract excerpt

"In vivo" kinetics of T cell differentiation and TCR expression in the normal murine thymus were re-evaluated using a new technique for simultaneous detection of bromodeoxyuridine and two surface markers. The transition from CD4-8- precursors to CD4+8+ immature cells was directly observed during cell proliferation, and shown to proceed through transitory intermediates expressing no or low amounts of CD4. CD3-TCR...

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