Article
Origin of regulatory T cells with known specificity for antigen.
Nature immunology - 1 Aug 2002
Apostolou Irina, Sarukhan Adelaida, Klein Ludger, von Boehmer Harald
Abstract excerpt
T cell receptor agonists can induce the differentiation of regulatory T (T(R)) cells. We report here that the immunoglobulin kappa-controlled expression of an agonist in different cell types correlated with the phenotype of the generated T(R) cells. We found that aberrant expression on thymic stroma yielded predominantly CD4(+)CD25(+) T(R) cells, which--under physiological conditions--may be induced by...
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