Article

Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferation

2025-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Primary cilia play a pivotal role in cellular signaling and development and disruptions in ciliary form and/or function leads to human ciliopathies. Here, we examine the role of Ttc21b , a key component of the intraflagellar transport-A complex, in mouse forebrain development using a Ttc21b alien null allele. Our findings reveal significant microcephaly in homozygous mutants is caused by disru...

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Literature Corpus work: 843d82f3-f286-5476-81f1-0ebd7b2ca40c
DOI: 10.1101/2025.01.14.632919

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