Inducer-dependent conditional-lethal mutant animal viruses.

doi:10.1073/pnas.88.4.1511

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Article

Inducer-dependent conditional-lethal mutant animal viruses.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1991

Zhang Y F, Moss B

Abstract excerpt

Regulatory elements of the Escherichia coli lac operon were used to construct an inducer-dependent conditional-lethal mutant animal virus. The gene encoding the repressor protein of the lac operon was integrated into the vaccinia virus genome so that it was expressed constitutively, and the lac operator was inserted next to the promoter of a gene that encodes an 11-kDa virion-associated protein of unknown...

Topics

Animals
Base Sequence
Cell Line
Escherichia coli
Genes, Lethal
Genetic Vectors
Isopropyl Thiogalactoside
Lac Operon
Molecular Sequence Data
Mutation
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open Reading Frames

Plasmids

Polymerase Chain Reaction

Recombination, Genetic

Restriction Mapping

Transcription, Genetic

Vaccinia virus

Source

Open in PubMed Open full text

Identifiers

PMID: 1899929
DOI: 10.1073/pnas.88.4.1511
PMCID: PMC51049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1899929-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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