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Article

Inducer-dependent conditional-lethal mutant animal viruses.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1991

Zhang Y F, Moss B

Abstract excerpt

Regulatory elements of the Escherichia coli lac operon were used to construct an inducer-dependent conditional-lethal mutant animal virus. The gene encoding the repressor protein of the lac operon was integrated into the vaccinia virus genome so that it was expressed constitutively, and the lac operator was inserted next to the promoter of a gene that encodes an 11-kDa virion-associated protein of unknown...

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Identifiers

PMID: 1899929
DOI: 10.1073/pnas.88.4.1511
PMCID: PMC51049

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